DeSande R has worked on paintings concerning influential people in the community, Billie Holiday, and Nina Simone. She also ventured into analog photography within the subject of portraiture.

Her recent works encompass using pen to do expressive drawings and linoleum block prints. DeSande is currently working on a series of linoleum block prints portraying the natural styles of African American women, prominent African Americans in history, and African symbols and the history behind it.